Knowledge about the position and shape of the human brain cortex can be used for a wide variety of purposes in medicine and science, from learning about the function of the brain, to planning for surgery, to studying how diseases affect the brain. This talk presents CRUISE, an automatic method to find and geometrically represent the cortex of the brain from magnetic resonance images. Tissue classification and segmentation using geometric deformable models are at the core of this approach, and topological correctness is an underlying theme. It is shown how geometric properties of the cortex can be used to match the gyri and sulci (folding patterns) of multiple subjects. The result is an alignment of the cortices, which can then be used to apply a coordinate system to a given subject, to perform population analyses of function in a standardized coordinate system, or to assist in normalizing the whole brain to a standard atlas of the brain. CRUISE has been run on over 1,000 magnetic resonance brain images for testing, validation, and carrying out scientific studies.
Jerry L. Prince received the B.S. degree from the University of Connecticut in 1979 and the S.M., E.E., and Ph.D. degrees in 1982, 1986, and 1988, respectively, from the Massachusetts Institute of Technology, all in electrical engineering and computer science. He has worked as an engineer at the Brigham and Women's Hospital, MIT Lincoln Laboratories, and The Analytic Sciences Corporation (TASC). He joined the faculty at the Johns Hopkins University in 1989, where he is currently William B. Kouwenhoven Professor in the Department of Electrical and Computer Engineering and holds joint appointments in the Departments of Radiology, Biomedical Engineering, Computer Science, and Applied Mathematics and Statistics. Dr. Prince is a
Fellow of the IEEE and a member of Sigma Xi. He also holds memberships in Tau Beta Pi, Eta Kappa Nu, and Phi Kappa Phi honor societies. He was an Associate Editor of IEEE Transactions on Image Processing from 1992-1995, an Associate Editor of IEEE Transactions on Medical Imaging from 2000-2004 and is currently a member of the Editorial Board of Medical Image Analysis. Dr. Prince received a 1993 National Science Foundation Presidential Faculty Fellows Award and was Maryland's 1997 Outstanding Young Engineer. He is also co-founder of Diagnosoft, Inc., a medical imaging software company. His current research interests are in image processing and computer vision with primary application to medical imaging and has published over 200 articles and abstracts on these subjects.